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London - Rate Of Aging May Be Determined In The Womb And Linked To Birthweight, Study Reveals

Published on: July 9, 2013 10:26 PM
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London - Scientists have found that key metabolites in blood—chemical ‘fingerprints’ left behind as a result of early molecular changes before birth or in infancy—could provide clues to a person’s long-term overall health and rate of aging in later life.

Published today in the International Journal of Epidemiology, the international study of twins led by King’s College London highlights how a technique called metabolomic profiling has revealed a collection of 22 metabolites linked to aging. One of these, linked to aging traits such as lung function and bone mineral density, is also strongly associated with birthweight—a well-known developmental determinant of healthy aging.

This finding suggests that levels of this novel metabolite, which may be determined in the womb and affected by nutrition during development, could reflect accelerated aging in later adult life. Scientists say the findings show it is possible that these markers of aging can be identified with simple blood tests in the future, which may provide further clues to the aging process and could pave the way for development of therapies to treat age-related conditions.

Professor Tim Spector, Head of the Department of Twin Research at King’s College London, said: ‘Scientists have known for a long time that a person’s weight at the time of birth is an important determinant of health in middle and old age, and that people with low birth weight are more susceptible to age related diseases. So far the molecular mechanisms that link low birthweight to health or disease in old age had remained elusive, but this discovery has revealed one of the molecular pathways involved.’

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Funded by the European Commission, Researchers from the Department of Twin Research at King’s carried out metabolomic profiling—the study of metabolites that specific cellular processes or changes leave behind in the blood. Analysing blood samples donated by over 6,000 twins, they identified 22 metabolites directly linked to chronological age—the concentrations of the metabolites were higher in older people than in younger people.

One particular metabolite—C-glyTrp—is associated with a range of age-related traits such as lung function, bone mineral density, cholesterol and blood pressure. Its role in aging is completely novel. Crucially, researchers found it was also associated with lower weight at birth when they compared the birth weights of identical twins.

To explore the link between birth weight and the metabolite, the researchers showed via genetic tests that the gene influencing the levels could be modified epigenetically (whereby genes are switched on or off by chemical switches triggered by the person’s environment or lifestyle). These epigenetic changes may then influence metabolism during a person’s lifetime, which in turn influences their risk of age-related diseases.

Ana Valdes, lead researcher from King’s, said: ‘Human aging is a process influenced by genetic, lifestyle and environmental factors, but genes only explain a part of the story. Molecular changes that influence how we age over time are triggered by epigenetic changes. This study has for the first time used analysis of blood and epigenetic changes to identify a novel metabolite that has a link to birthweight and rate of aging.

‘This unique metabolite, which is related to age and age related diseases, was different in genetically identical twins that had very different weight at birth. This shows us that birth weight affects a molecular mechanism that alters this metabolite. This may help us understand how lower nutrition in the womb alters molecular pathways that result in faster aging and a higher risk of age-related diseases fifty years later.

‘Understanding the molecular pathways involved in the aging process could ultimately pave the way for future therapies to treat age-related conditions. As these 22 metabolites linked to aging are detectable in the blood, we can now predict actual age from a blood sample pretty accurately and in the future this can be refined to potentially identify future rapid biological aging in individuals.’



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Read Comments (6)  —  Post Yours »

1

 Jul 09, 2013 at 10:46 PM Anonymous Says:

So everything from your bashert and how long you will live is determined while you are still in the womb.

2

 Jul 10, 2013 at 07:31 AM Heshy Friedman Says:

Baloney Baloney and more Baloney. I bet you the same scientists in this study all believe in evolution and that we humans originate from apes and not Adam and Chava. I know many old people born weak and underweight and live long lives. Take Rabbi Elyashiv 102. Take Rabbi Sheinberg 101 Take Rabbi Yoel Teitelbaum 93. Take Rimnitzer rebbe 94. Take Rabbi Shach 103. Take Rabbi Keduri 103. Take lubavitcher rebbe 92. Take Rabbi Moshe Feinstein 91. Take Rabbi Avigdor Miller 92. What we as Jews know that living in Eretz yisroel you can have a longer life span. If you compare gedolim living here most lived into their nineties. In israel most lived passed 100. Science and medicine changes every ten years. Torah remains eternal. It is we Torah jews who know more about the universe than all these so called scientists. We always knew world was round and about gravity (see zohar beginning vayikra) we always knew there are almost infinite stars. We always knew of vents under ocean floor shooting hot water. I can list hundreds of things and Torah sources that we knew while the secular world was clueless.

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 Jul 10, 2013 at 09:14 AM Anonymous Says:

Reply to #2  
Heshy Friedman Says:

Baloney Baloney and more Baloney. I bet you the same scientists in this study all believe in evolution and that we humans originate from apes and not Adam and Chava. I know many old people born weak and underweight and live long lives. Take Rabbi Elyashiv 102. Take Rabbi Sheinberg 101 Take Rabbi Yoel Teitelbaum 93. Take Rimnitzer rebbe 94. Take Rabbi Shach 103. Take Rabbi Keduri 103. Take lubavitcher rebbe 92. Take Rabbi Moshe Feinstein 91. Take Rabbi Avigdor Miller 92. What we as Jews know that living in Eretz yisroel you can have a longer life span. If you compare gedolim living here most lived into their nineties. In israel most lived passed 100. Science and medicine changes every ten years. Torah remains eternal. It is we Torah jews who know more about the universe than all these so called scientists. We always knew world was round and about gravity (see zohar beginning vayikra) we always knew there are almost infinite stars. We always knew of vents under ocean floor shooting hot water. I can list hundreds of things and Torah sources that we knew while the secular world was clueless.

Your comment is dangerous and fool hardly, Firstly, we don't go around bragging about peoples ages as you INVITE an ayin hara. Secondly, for every one of the examples you gave above, we can give more examples of other saintly Yidden who died prematurely. R'L

4

 Jul 10, 2013 at 09:43 AM sheepheadsbayyid Says:

Reply to #2  
Heshy Friedman Says:

Baloney Baloney and more Baloney. I bet you the same scientists in this study all believe in evolution and that we humans originate from apes and not Adam and Chava. I know many old people born weak and underweight and live long lives. Take Rabbi Elyashiv 102. Take Rabbi Sheinberg 101 Take Rabbi Yoel Teitelbaum 93. Take Rimnitzer rebbe 94. Take Rabbi Shach 103. Take Rabbi Keduri 103. Take lubavitcher rebbe 92. Take Rabbi Moshe Feinstein 91. Take Rabbi Avigdor Miller 92. What we as Jews know that living in Eretz yisroel you can have a longer life span. If you compare gedolim living here most lived into their nineties. In israel most lived passed 100. Science and medicine changes every ten years. Torah remains eternal. It is we Torah jews who know more about the universe than all these so called scientists. We always knew world was round and about gravity (see zohar beginning vayikra) we always knew there are almost infinite stars. We always knew of vents under ocean floor shooting hot water. I can list hundreds of things and Torah sources that we knew while the secular world was clueless.

Nice, only mention gedolem that lived long. What about the ones who died early. And there are many nazis who lived and still are living to a ripe old age.yester

The sun revolves around the
earth and hides at night. It must be so since torah jews of yesteryear knew more about science than anybody today.

I hope you do not use todays doctors.

5

 Jul 10, 2013 at 11:07 AM Heshy Friedman Says:

I am amazed how modern orthodox or ex orthodox commentators on frum blogs try to spread their brainwashed kefirah to frum yidden. I can show you hundreds of things that the secular world even not so long ago was ignorant. Be it the world being round and people living on both sides of the globe and so on. I'm just rushing now to a shiuer but I want you ex orthos to know that everything is plan and purpose including nazis who lived to an old age.

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 Jul 10, 2013 at 05:32 PM Secular Says:

The Talmud in Nida 16b


דדריש ר' חנינא בר פפא א] אותו מלאך הממונה על ההריון לילה שמו ונוטל טפה ומעמידה לפני הקב"ה ואומר לפניו רבש"ע טפה זו מה תהא עליה גבור או חלש חכם או טיפש עשיר או עני ואילו רשע או צדיק לא קאמר כדר' חנינא דא"ר חנינא הכל בידי שמים חוץ מיראת שמים שנאמר ועתה ישראל מה ה' אלהיך שואל מעמך כי אם ליראה וגו'

7

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